Inhibition of type I and type III interferons by a secreted glycoprotein from Yaba-like disease virus.

Immunogenicity and Efficacy of Baculovirus Derived Glycoprotein D of Herpes Simplex Virus Type-I in Mice

Partial inhibition of human immunodeficiency virus replication by type I interferons: impact of cell-to-cell viral transfer.

Type I interferons (IFN) inhibit several steps of the human immunodeficiency virus type 1 (HIV) replication cycle. Some HIV proteins, like Vif and Vpu, directly counteract IFN-induced restriction factors. Other mechanisms are expected to modulate the extent of IFN inhibition. Here, we studied the impact of IFN on various aspects of HIV replication in primary T lymphocytes. We confirm the potent...

A Review of the Mechanisms Involved in the Immunopathogenesis of SARS-CoV-2

Coronaviruses belong to the Coronaviridae family and three SARS-CoV, MERS-CoV and SARS-CoV-2 pathogens are found in this family, all of which cause respiratory disorders in human beings. SARS-CoV-2 is a RNA virus of approximately 80-160 nm in size and genomic size of approximately 27-35 kb which causes COVID-19. Symptoms of COVID-19 include fever, dry cough, fatigue and muscle weakness, shortne...

Expression of the Herpes Simplex Virus Type 2 Glycoprotein D in Baculovirus Expression System and Evaluation of Its Immunogenicity in Guinea Pigs

Background: Herpes simplex virus type 2 (HSV-2) is highly prevalent and major cause of genital herpes in humans. The life-long nature of infection and the increasing prevalence of genital herpes imply that vaccination is the best strategy for controlling the spread of infection and limiting HSV disease. HSV glycoprotein D (gD) is one of the most important viral immunogen which has an essential ...

فراوانی ژن‌های کد کننده سیتوتوکسین‌های exoT، exoY، exoS وexoU سیستم ترشحی تیپ 3 در سودوموناس آئروجینوزا جدا شده از بیماران سوختگی

Background and Objective: Pseudomonas aeruginosa is an opportunistic pathogen causing nosocomial burn infections. Disease results from the production of numerous virulence factors, some of which are injected directly into the eukaryotic host cells via the type III secretion system (T3SS).The aim of this study was to determine the prevalence of cytotoxins encoding exoT, exoY, exoS and exoU genes...